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MSB may refer to: * Main Support Battalion, part of the U.S. Army logistics * Maritime Services Board, former government agency in New South Wales, Australia * Marshall Swift-Boeckh, a cost estimation services provider and subsidiary of CoreLogic * Le Mans Sarthe Basket a French basketball team * The Magic School Bus, series of children's books about science * Media Stream Broadcast, a proprietary, multicast communications protocol owned by Microsoft * 1,4-Bis(2-methylstyryl) benzene, also known as p-Bis(o-methylstyryl) benzene and abbreviated Bis-MSB, a wavelength shifting compound used in liquid scintillators * Microsoft Surface Book * Bureau of Investigation and Statistics (Military Investigation and Statistics Bureau), the military intelligence agency of the Republic of China before 1946. * Millennium Seed Bank, an international conservation project for storing plant seeds * Molecular Systems Biology, an open-access, peer-reviewed scientific journal * Money services business, a legal term used by financial regulators to describe businesses that transmit or convert money * Most significant bit, the bit with the highest significance in a word * Most significant byte, the highest byte in a multi-byte number * Mrs. Stewart's Bluing, a brand of fabric bluing agent that whitens fabrics with a dye called Prussian blue (ferric hexacyanoferrate) * Myanmar Standard Bible, a translation of the Bible into the Burmese language * Myndigheten för samhällsskydd och beredskap, the Swedish Civil Contingencies Agency